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KMID : 0383820080650050410
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Tuberculosis and Respiratory Diseases
2008 Volume.65 No. 5 p.410 ~ p.415
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Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report
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Oh Ji-Hye
Kim Kyung-Chan
Kim Sung-Woo
Hyun Dae-Sung
Lee Sang-Chae
Bae Sung-Hwa
Jung Kyung-Jae
Kwon Kun-Young
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Abstract
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Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient’s pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT.
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KEYWORD
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Bone marrow transplantation, Bronchiolitis obliterans, Pulmonary function, Azithromycin
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